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Cutting lipitor pills in half

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Where was lipitor discovered

"Unfortunately, there are some. In the 1970s the Japanese microbiologist Akira Endo first discovered natural products with a powerful inhibitory effect on HMGR in a fermentation broth of Penicillium citrinum, during his search for antimicrobial agents. When it was in development, the cholesterol-lowering medicine was viewed as such an also-ran it almost didn't make it into patient testing. Bruce Roth, the inventor of Lipitor, calls the people who make those tough decisions ‘drug hunters’ and says that it takes between 10 and 15 years to train them. By Jie Jack Li, Oxford University Press, 2009, 201 pages, . 95 hardcover (ISBN: 978-0-19532-357-3) Li, a medicinal chemist, has written a. By the time Lipitor went on sale in early 1997, it was the fifth drug in a. (AP) — Lipitor, the best-selling drug in the history of pharmaceuticals, is the blockbuster that almost wasn't. It is on the World Health Organization's List of Essential Medicines In 1947, Kai Pedersen, student of Svedberg, found a labile lipid protein, which was considered an artefact in Schlieren profiles. In 1913, Russian pathologist Nikolai Anitschkow, the first person to describe foam cells [4], in a brilliant study, demonstrated cholesterol’s role in the development of atherosclerosis TRIUMPH OF THE HEART: The Story of Statins, [+]Enlarge. The first product was named compactin ( ML236B or mevastatin ) In 1978, Alfred Alberts, along with his colleagues at Merck Research Laboratories, discovered a potent inhibitor of HMG-CoA reductase in a fermentation broth of Aspergillus terreus, which was. Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996. Therefore, he concluded that serum was not suitable to study due to interference with “protein X” [10, 13] TRENTON, N. In the mid-19th century, Virchow discovered that cholesterol was found in the arterial walls of individuals that died from vaso-occlusive diseases such as myocardial infarction [3].

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